NERVE ENDINGS SKIN
NERVE ENDINGS FREE

The prepuce is no exception to this general pattern of having FNE over its entire surface, but like most other skin (except the two exceptions above) it has varying numbers and distribution of corpuscular endings which are in lower numbers than the FNE.

NERVE ENDINGS FREE

All skin appears to have many free nerve endings evenly distributed over their surfaces regardless of the local function two epithelia, however, have virtually no fine touch-the cornea of the eye and the glans penis-having almost nothing but free nerve endings.

In my estimation, I extrapolated the numbers of Meissner corpuscular endings from the finger tip to the prepuce as these are the principal mediators of fine touch (and, therefore, of sexual sensation). … Paul Fleiss did not differentiate between the types either and simply took Bazett's total number for his estimate. … I made my informal ‘back of the envelope’ estimation in response to a question during discussion outside the meeting. I made my estimate at the Symposium held in Oxford UK, Summer 1998. In a further e-mail from to the author Ken McGrath writes about his estimate: Furthermore, such a vast number is totally unnecessary to achieve the known high sensitivity of the prepuce. it is impossible for the foreskin to support such a huge number: there is not enough surface area to mount so many receptors (they would nearly outnumber the epithelial cells!) and the known number of axons ranging into the prepuce could not connect to that number. More research is needed to clarify the actual number and distribution.Īnd in a further actual statement about the 20,000 figure McGrath writes: Some writers have erroneously inflated this estimate to 20,000 or more. In orders of magnitude, the number has to be more than 1000 and less than 10,000. Therefore, at a minimum, the most sensitive area of the prepuce would have at least 3000 corpuscular endings. The area of the frenular delta is equivalent to or greater than three fingertip areas, i.e. For each centimetre of ridge there would be thirty Meissner's corpuscles and thus 900-1200 per cm2 of tip. The frenular delta and frenular band are more sensitive than a fingertip one square centimetre of fingertip has about 30-40 ridges with approximately three Meissner's corpuscles in every millimetre of ridge. The following method has been used to estimate the number of corpuscular nerve endings in the foreskin. In 2017, Ken McGrath confirms his estimate from 1998 : , that Ken McGrath has given a previous higher estimate in a 2008 e-mail is refused by Ken McGrath as not being by him. McGrath's estimate „>1000100010,000 and then to >20,000 neither of these is anywhere near the truth, because they are an order of magnitude too high.

Sometimes the impression is given that a figure which is the maximum is average, ,, or nerves are referred to instead of nerve endings – a big difference in number. note, which does not mention the number, like at first 1997 in the article of Fleiss. So it is often linked in publications with a ref. Often, the legend is made more believable by giving the impression that it is verifiable. These and many other publications have spread the legend of “20,000 …” widely. According to the book: 'the foreskin contains … tens of thousands of specialized erogenic nerve endings …'(S.2f).Ģ009 Marilyn Milos wrote: “20,000-70,000 highly specialized erogenous nerve endings encircle the opening of the foreskin.”, also in the years 2012, 2013, 2015. The widespread dissemination of the legendĢ002 Fleiss and Hodges published: “What Your Doctor May Not Tell You About Circumcision“ b. This is all the more true, if it is not known where exactly the tissue was taken from on the foreskin, and how old it was. It is completely insufficient, outgoing from only one single 1cm²-piece of prepuce tissue and the greatly different distribution of the nerve endings therein, to derive from it generally a number of nerve endings of the foreskin as a whole. So he obviously came to 'more than 20,000 nerve endings'. In orders of magnitude, the number has to be >1,000 and 200= >20,000). 1.4.1 „>100010,000 and >20,000] is anywhere near the truth, because they are an order of magnitude too high.1.3 The widespread dissemination of the legend.1.2.5 Nerve endings in the foreskin / 1cm².1.2.3 Nerve endings in the foreskin / Quarter (25-US-Ct.).1.2.1 The number of nerve endings in normal skin.1.2 How did Fleiss come to this number, which is nowhere documented?.1 Demythologization of the '20,000 nerve endings” legend.